In Central Nervous System Cholinergic system is very important and vital component for memory and cognitive functions. Disruption of this system is seen in case of Dementia, Alzheimer's Disease.
Cholinergic system includes neurotransmitter acetylcholine, Muscarinic receptors and Nicotinic receptors. Acetylcholine binds to this receptors and activate them. This receptors are located on cholinergic neurons. Nicotinic receptors are most important for memory, cognition and Higher Intellectual functions.Activation of Nicotinic receptors causes release of other neurotransmitters like dopamine, norepinephrine, serotonin, etc.
Nicotinic receptors have various subtypes. Among all subtypes Apha-7 subunit is of great importance.Scientists have discovered that Alpha 7 Nicotinic receptors regulate most important Higher Intellectual functions.There is evidence of involvement of Alpha 7 Nicotinic receptors in various Nervous system disorders like schizophrenia, Alzheimer's Disease, Dementia, Learning Disability. Density of Alpha 7 Receptors is reduced in these diseases.
Agonist of Alpha 7 Nicotinic Receptors causes upregulation of this receptors. Most powerful agonist of these receptors is Nicotine. Nicotine has been found to improve symptoms of above mentioned disease. It has been found to improve working memory, Attention, Cognitive Abilities. But use of Nicotine for this purpose is not recommended as benifits of nicotine are far away from well known health risks. Scientists are discovering molecule that targets Alpha 7 receptors other than Nicotine. Discovery and Developement of Drug targeting Alpha 7 Nicotinic receptors will bring great revolution in field of Human Cognitive Enhancement.
Cholinergic system includes neurotransmitter acetylcholine, Muscarinic receptors and Nicotinic receptors. Acetylcholine binds to this receptors and activate them. This receptors are located on cholinergic neurons. Nicotinic receptors are most important for memory, cognition and Higher Intellectual functions.Activation of Nicotinic receptors causes release of other neurotransmitters like dopamine, norepinephrine, serotonin, etc.
Nicotinic receptors have various subtypes. Among all subtypes Apha-7 subunit is of great importance.Scientists have discovered that Alpha 7 Nicotinic receptors regulate most important Higher Intellectual functions.There is evidence of involvement of Alpha 7 Nicotinic receptors in various Nervous system disorders like schizophrenia, Alzheimer's Disease, Dementia, Learning Disability. Density of Alpha 7 Receptors is reduced in these diseases.
Agonist of Alpha 7 Nicotinic Receptors causes upregulation of this receptors. Most powerful agonist of these receptors is Nicotine. Nicotine has been found to improve symptoms of above mentioned disease. It has been found to improve working memory, Attention, Cognitive Abilities. But use of Nicotine for this purpose is not recommended as benifits of nicotine are far away from well known health risks. Scientists are discovering molecule that targets Alpha 7 receptors other than Nicotine. Discovery and Developement of Drug targeting Alpha 7 Nicotinic receptors will bring great revolution in field of Human Cognitive Enhancement.
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